汪虎，男，博士，杭州师范大学基础医学院副院长，博士生导师
国家自然科学基金“优青”项目获得者、
浙江省高校领军人才计划高层次拔尖人才、
浙江省“万人计划”青年拔尖人才
联系方式
Email: 20120066@hznu.edu.cn
招生专业和研究方向
细胞生物学。研究工作主要聚焦在成体干细胞衰老的分子机制及抗衰老药物的研发及应用。近5年以第一或通讯作者（含共同）在领域内权威期刊Cell Stem Cell（2篇）、Cell Research、Blood、Nature Communications、Signal Transduction and Targeted Therapy（STTT）、EMBO Reports等发表SCI论文20余篇。
主要工作简历
2012年获浙江大学或博士学位。近年来从事干细胞衰老的分子机制及抗衰老药物的研发：从端粒及非端粒依赖的衰老机制研究入手，研究造血干细胞衰老的命运决定；同时在理论研究的基础上开发新型的抗衰老化合物及药物在衰老动物及非人灵长类模型上的应用研究。承担国家重点研发计划干细胞及转化研究重点专项项目2项，国家自然科学基金衰老重大研究计划项目及国家自然科学基金面上项目等，累计获科研经费500余万元。并多次应邀参加干细胞及衰老领域学术会议。2020年入选浙江省“万人计划”青年拔尖人才资助。现任中国老年医学学会委员；中国生理学会会员；中国细胞生物学学会会员；中国生物物理学学会会员；国际血液学学会（ISEH）会员。
代表性论著(* corresponding author)
[1] Wang Hu#*，Diao Daojun#, Shi Zhencan, Zhu Xudong, Gao Yawei, Gao Shaorong, Liu Xiaoyu, Wu You, Rudolph Karl Lenhard, Liu Guanghui, Li Tangliang, Ju Zhenyu*. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell 18, 495-507, doi:10.1016/j.stem.2016.03.005 (2016). (IF=23.29）
[2] Wang Hu#*, Zuo Hongna #, Liu Jin , Fei Wen, Yawei Gao, Xudong Zhu, Bo Liu, Feng Xiao,Wengong Wang,Gang Huang, Bin Shen*, Zhenyu Ju*. Loss of YTHDF2 mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration. Cell Res. 2018 Aug 27. (IF=20.507）
[3] Rongrong Le#*, Yixin Huang#, Yanping Zhang#, Wang Hu #(co-first author), Jiaming Lin#, Yu Dong, Ziyi Li, Mingyue Guo, Xiaochen Kou, Yanhong Zhao, Mo Chen, Qianshu Zhu, Anqi Zhao, Jiqing Yin, Jiatong Sun, Zhongqu Su, Kerong Shi, Yawei Gao, Jiayu Chen, Wenqiang Liu, Lan Kang, Yixuan Wang, Chong Li, Xiaoyu Liu, Rui Gao, Hong Wang, Zhenyu Ju*, Shaorong Gao*.Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells. Cell Stem Cell, 2020,12,24.(IF=21.4).
[4] Tang H#, Wang H#(co-first author), Cheng X#, Fan X#, Yang F#, Zhang M, Chen Y, Tian Y, Liu C, Shao D, Jiang B, Dou Y, Cong Y, Xing J, Zhang X, Yi X, Songyang Z, Ma W, Zhao Y, Wang X, Ma J, Gorospe M, Ju Z, Wang W. HuR regulates telomerase activity through TERC methylation. Nat Commun. 2018 Jun 7;9(1):2213. (IF=12.3）
[5]Ying Wang*, Jin-ping Zheng, Ying Luo, Junyi Wang, Lingjie Xu, Jinyong Wang, John M. Sedivy, Zhangfa Song*, Hu Wang* & Zhenyu Ju*. L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia. Signal Transduction and Targeted Therapy. 2020 September 19;5(1):205. (IF=13.493)
[6] Diao Daojun #, Wang Hu #(co-first author), Li Tangliang #, Zhencan Shi, Xiaoqing Jin, Tobias Sperka, Xudong Zhu, Meimei Zhang, Fan Yang, Yusheng Cong, Li Shen, qimin zhan, Jing Yan, Zhangfa Song，Ju Zhenyu *. Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan. EMBO Reports .2018, Aug 20. (IF=8.7）
[7] Wan X#, Zhu X#*, Wang H#(co-first author), Feng Y#, Zhou W, Liu P, Shen W, Zhang L, Liu L, Li T, Diao D, Yang F, Zhao Q, Chen L, Ren J, Yan S, Li J, Yu C*, Ju Z*.PGC1α protects against hepatic steatosis and insulin resistance via enhancing IL10-mediated anti-inflammatory response. FASEB J. 2020 Jul 7. (IF=4.966)
