一、导师基本情况
姓名：王欢欢，生理学博士，副教授（硕士生导师）
办公电话：0571-28868887
邮箱：huanval@hznu.edu.cn.
指导专业（按照招生目录上的名称填写）：
生理学
二、研究领域
1. 神经退行性疾病
2.
3.
……
三、主讲课程
1. 生理学
2. 机能学实验
3.
……
四、教育和工作经历
2017/12至今 杭州师范大学医学院基础医学系副主任
2019/12至今 杭州师范大学医学院基础医学系生理教研室 副教授
2012/09-2019/12 杭州师范大学医学院基础医学系生理教研室 讲师
2008/09-2012/06 德国慕尼黑大学医学院Adolf-Butenandt Institute生化系；
德意志神经退行性疾病研究中心 自然科学博士
2006/09-2008/06 浙江大学药学院药理毒理与生化药学研究所 药理学 医学硕士
2002/10-2006/06 浙江大学药学院 药学 理学学士
五、学术简介（限200字内）
（含人才称号和荣誉）
主要从事神经退行性疾病相关分子机制的研究，研究重点为AD相关神经炎症和神经元凋亡，试图阐明环境因素或自身代谢因素对AD发生发展的影响。目前已获得国家自然科学基金青年基金1项，浙江省自然科学基金2项，杭州市高层次留学回国人员（团队）在杭创业创新项目1项，相关研究成果已发表于EMBO J，FASEB Journal ，Journal of Alzheimer’s Disease等。
六、主持教学科研项目（省部级以上）
1. 2019-2021 主持浙江省自然科学基金一般项目 iRhom2/ADAM17在胶质细胞激活对环境PM2.5慢性暴露致神经损伤的作用机制研究（LY19H260003）9万
2. 2014-2016 主持国家自然科学基金青年基金 白介素-1受体激活调控淀粉样前体蛋白a剪切酶对阿尔茨海默综合征神经保护作用机制研究（81302781）23万
3. 2013-2016 主持浙江省自然科学基金青年基金 ADAM17在TLR4介导Aβ致神经小胶质细胞激活与吞噬过程中的作用（Q13C090006）5万
七、代表性论著
1. 2022.5.3 Xintong Ji, Chenxia Li, Xiaozheng Zhu, Wenlei Yu, Yanyu Cai, Xinyi Zhu, Linjie Lu, Qiwei Qian, Yu Hu, Xuan Zhu*, Huanhuan Wang∗ Methylcobalamin Alleviates Neuronal Apoptosis and Cognitive Decline Induced by PM2.5 Exposure in Mice. Journal of Alzheimer’s Disease 2022, 86(4): 1783-1796.
2. 2021.10.26 Wenlei Yu, Linjie Lu, Xintong Ji, Qiwei Qian, Xiaohan Lin, Huanhuan Wang* Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury. Journal of Alzheimer’s disease 2021, 84(1): 51-59.
3. 2021.8.19 Xiaozheng Zhu, Yikai Shou, Xintong Ji, Yu Hu*, Huanhuan Wang* S-adenosylmethionine decarboxylase 1 and its related spermidine synthesis mediate PM2.5 exposure-induced neuronal apoptosis. Ecotoxicology and Environmental Safety 2021, 224: 112678.
4. 2020.10.1 Yikai Shou#, Xiaozheng Zhu#, Danna Zhu, Hongping Yin, Yingying Shi, Minyan Chen, Linjie Lu, Qiwei Qian, Dongjiu Zhao, Yu Hu*, Huanhuan Wang* Ambient PM2.5 chronic exposure leads to cognitive decline in mice: From pulmonary to neuronal inflammation. Toxicology Letters 2020, 331: 208-217.
5. 2020.9.1 Xiaozheng Zhu, Xintong Ji, Yikai Shou, Yilu Huang, Yu Hu*, Huanhuan Wang* Recent advances in understanding the mechanisms of PM2.5-mediated neurodegenerative diseases. Toxicology Letters 2020, 329: 31-37.
6. 2020.4.1 Huanhuan Wang#*, Guoping Peng#, Bing Wang, Hongping Yin, Xingyue Fang, Fangping He, Dongjiu Zhao, Qibing Liu, Liyun Shi* IL-1R-/- alleviates cognitive deficits through microglial M2 polarization in AD mice. Brain Research Bulletin 2020, 157: 10-17.
7. 2019.7.3 Chaoqun Wang, Yikai Shou, Jie Pan, Yue Du, Cuiqing Liu, Huanhuan Wang* The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism. Nutritional Neuroscience 2019, 22(7): 453-463.
8. 2019.6.15 Yikai Shou#, Yilu Huang#, Xiaozheng Zhu, Cuiqing Liu, Yu Hu*, Huanhuan Wang* A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease. Ecotoxicology and Environmental Safety 2019, 174: 344-352.
9. 2019.3.15 Huanhuan Wang#, Yikai Shou#, Xuan Zhu*, Yuanyuan Xu, Lihua Shi, Shasha Xiang, Xiao Feng, Jianzhong Han Stability of vitamin B12 with the protection of whey proteins and their effects on the gut microbiome. Food Chemistry 2019, 276: 298-306.
10. 2018.11.20 Huanhuan Wang#, Wenhai Huang#, Meihao Liang, Yingying Shi, Chixiao Zhang, Qin Li, Meng Liu, Yikai Shou, Hongping Yin, Xiaozheng Zhu, Xiaoyan Sun, Yu Hu, Zhengrong Shen* (+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling. Cell & Bioscience 2018, 8(60): 1-15.
11. 2017.2.1 Huanhuan Wang*, Bing Wang, Hongping Yin, Guoqing Zhang, Liping Yu, Xiangmin Kong, Haiying Yuan, Xingyue Fang, Qibing Liu, Cuiqing Liu, Liyun Shi* Reduced neurotrophic factor level is the early event before the functional neuronal deficiency in high-fat diet induced obese mice. Metabolic Brain Disease 2017, 32: 247-257.
12. 2016.5.1 Meng Qian, Xiaoqiang Shen, Huanhuan Wang* The Distinct Role of ADAM17 in APP proteolysis and microglial activation related to Alzheimer’s disease. Cellular and Molecular Neurobiology 2016, 32: 471-482.
