王志国，博士、副研究员、硕士研究生导师，九三学社社员
一、导师基本情况
姓名：王志国，理学博士，副研究员（硕士生导师）
邮箱：zhgwang@hznu.edu.cn.
指导专业：生理学、衰老生物学
二、研究领域
1. 药物与靶蛋白和端粒G-四链体的作用机制研究
2. 蛋白质定向进化及酶催化机制研究
三、主讲课程
1. 生理学
2. 生物信息学
3. 机能学实验
四、教育和工作经历
2000年9月--2004年6月，曲阜师范大学，工学学士
2004年9月--2007年6月，曲阜师范大学，理学硕士
2007年9月--2010年6月，中国科学院西北高原生物研究所，理学博士
2010年7月至今，杭州师范大学基础医学院，副研究员
五、学术简介（限200字内）
2016年获评杭州市教育局系统优秀教师
六、主持教学科研项目（省部级以上）
1. 国家自然科学基金青年项目，人类醛酮还原酶对葡萄糖分子的催化机制研究，23万元，2012.01–2014.12。
2. 浙江省自然科学基金面上项目，hnRNP A2*对人类端粒 G-四链体的解折叠机制研究，9万元，2018.1–2020.12。
七、代表性论著
1. Jian Xu,1,* Jiajie Fan,1 Yujiao Lou,1 Weihua Xu,1 Zhiguo Wang,1 Danyang Li, Haonan Zhou, Xianfu Lin, Qi Wu.* Light-driven decarboxylative deuteration enabledby a divergently engineered photodecarboxylase. Nat. Commun. 2021, 12, 3983.
2. Lijuan Yan, Yijing Wang, Shiqing Zhang, Xinyi Li, Jingjing Wei, Zhiguo Wang,* Yongjun Liu.* Inactivation mechanism of neuronal nitric oxide synthase by (S)-2-amino-5-(2-(methylthio)acetimidamido)pentanoic acid: chemical conversion of the inactivator in the active site. Inorg. Chem. 2021, 60, 9345–9358.
3. Chenni Zheng,1 Zhiguo Wang,1,* Qian Wang, Shenyong Wang, Shuhua Lao, Jin He, Zhenming Chen.* Efficient preparation of the chiral intermediate of luliconazole with Lactobacillus kefir alcohol dehydrogenase through rational rearrangement of the substrate binding pocket. Mol. Catal. 2021, 509, 111639.
4. Xiaoyang Chen,1 Zhiguo Wang,1 Yujiao Lou, Yongzhen Peng, Qiaoyan Zhu, Jian Xu,* Qi Wu.* Intramolecular stereoselective Stetter reaction catalyzed by benzaldehyde lyase. Angew. Chem. Int. Ed. 2021, 60, 9326–9329.
5. Jian Xu,*,1 Yujiao Lou,1 Lanlan Wang,1 Zhiguo Wang,1 Weihua Xu, Wenqian Ma, Zhiqun Chen, Xiaoyang Chen,* Qi Wu.* Rational design of biocatalytic deuteration platform of aldehydes. ACS Catal. 2021, 11, 13348–13354.
6. Zhiguo Wang,1,* Guo Li,1 Zhou Tian,1 Xiaoqin Lou, Yining Huang, Lihui Wang, Jianfeng Li,* Tingjun Hou,* Jun-Ping Liu.* Insight derived from molecular dynamics simulation into the selectivity mechanism targeting c‑MYC G‑quadruplex. J. Phys. Chem. B 2020, 124, 9773–9784.
7. Lihui Wang,1 Ruping Chen,1 Guo Li,1 Zhiguo Wang, Jun Liu, Ying Liang, Jun-Ping Liu.* FBW7 mediates senescence and pulmonary fibrosis through telomere uncapping. Cell Metab. 2020, 32, 860‒877.
8. Jianfeng Li,1 Jiaxin Zhang,1 Guo Li,1 Yanyan Xu, Kai Lu, Zhiguo Wang,* Jun-Ping Liu.* Antimicrobial activity and mechanism of peptide CM4 against Pseudomonas aeruginosa. Food Funct. 2020, 11, 7245‒7254.
9. Guangcai Ma, Haiying Yu,* Cenyang Han, Xiaoxuan Wei, Zhiguo Wang.* Binding and metabolism of brominated flame retardant β-1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane in human microsomal p450 enzymes: insights from computational studies. Chem. Res. Toxicol. 2020, 33, 1487‒1496.
10. Jian Zhang, Zhiguo Wang, Tianyuan Su, Huanhuan Sun, Yuan Zhu, Qingsheng Qi,* Qian Wang.* Tuning the binding affinity of heme-responsive biosensor for precise and dynamic pathway regulation. iScience 2020, 23, 101067.
11. Guangcai Ma, Haiying Yu,* Xiaoqin Xu, Liming Geng, Xiaoxuan Wei, Jiale Wen, Zhiguo Wang.* Molecular basis for metabolic regioselectivity and mechanism of cytochrome p450s toward carcinogenic 4-(methylnitrosamino)-(3-pyridyl)-1-butanone (NNK). Chem. Res. Toxicol. 2020, 33, 436–447.
12. Jian Xu,1 Yongzhen Peng,1 Zhiguo Wang, Yujing Hu, Jiajie Fan, He Zheng, Xianfu Lin, Qi Wu.* Exploiting cofactor versatility to convert a FAD dependent Baeyer-Villiger monooxygenase into a ketoreductase. Angew. Chem. Int. Ed. 2019, 58, 14499–14503.
