一、导师基本情况
姓名:李建峰,生化与分子生物学博士,副教授(硕士生导师)
办公电话:0571-28861733
邮箱:swlijianfeng@163.com.
指导专业:衰老生物学
二、研究领域
1. 脑衰老与相关疾病(帕金森等神经变性疾病)机制研究
2. 溶酶体生物学
三、主讲课程
1. 生理学
2. 机能学实验
四、教育和工作经历
2003年9月--2007年6月,浙江师范大学,理学学士
2007年9月--2009年6月,南京师范大学,理学硕士
2009年9月--2012年6月,南京师范大学,理学博士
2013年1月—至今,杭州师范大学基础医学院,讲师、副教授
五、学术简介(限200字内)
主持国家自然科学基金2项、浙江省自然科学基金2项。入选杭州市高层次人才E类,杭州市131人才第三层次,杭州师范大学卓越人才第五层次。
六、主持教学科研项目(省部级以上)
1. 浙江省自然科学基金青年项目,抗菌肽 CMⅣ 的修饰改造及抗绿脓杆菌的作用研究,5万元,2013/01-2015/12。
2. 浙江省自然科学基金一般项目,PD模型小鼠脑内金属离子紊乱与α-突触核蛋白异常聚集的相关性研究,2021/01-2023/12。
3. 国家自然科学基金青年项目,ATP13A2 调控锰离子依赖性 α-synuclein 寡聚体形成作用的研究,22.8万元,2016.01–2018.12。
4. 国家自然科学基金面上项目,鞘脂运转紊乱与 α-synuclein 相变在帕金森氏病发生发展中的作用,55万元,2020/01-2023/12。
七、代表性论著
1. Li JF*, Zhang JX, Li G, Xu YY, Lu K, Wang ZG*, Liu JP*. Antimicrobial activity and mechanism of peptide CM4 against Pseudomonas aeruginosa. Food Funct. 2020 Aug 19;11(8):7245-7254.
2. Wang Z, Li JF*, Liu JP*. Effects of cation charges on the binding of stabilizers with human telomere and TERRA G-quadruplexes. J Biomol Struct Dyn. 2018.5; 28:1-14.
3. Jian Feng Li*, Jia Xin Zhang, Zhi Guo Wang, Ying Jia Yao, Xu Han, You Long Zhao, Jun Ping Liu*, Shuang Quan Zhang*, Identification of a cyclodextrin inclusion complex of antimicrobial peptide CM4 and its antimicrobial activity, Food Chemistry, 2017.
4. Liu H, Zhang J, Jian Feng Li (co-first author), Song J, Zhang S, Molecular structure, distribution, and immunology function of TNFSF13B (BAFF) in Nile tilapia (Oreochromis niloticus). Fish & Shellfish Immunology, 2016, 51, 240-250.
5. Jian Feng Li, Wang ZG, Liu HZ, Zhao YL, Zhang JX, Zhang SQ, Liu JP, Identification of interferon-γ-inducible-lysosomal thiol reductase (GILT) gene in goldfish (Carassius auratus) and its immune response to LPS challenge,Fish & Shellfish Immunology,2015,42,465-472.
6. Zhang J, Jian Feng Li (co-first author), Movahedi A, Sang M, Xu C, Xu J, Wei Z, Yin T, Zhuge Q, A novel inclusion complex (β-CD/ABP-dHC-cecropin A) with antibiotic propertiess for use as an anti-Agrobacterium additive in transgenic poplar rooting medium. Enzyme Microb Technol,2015,81:72–79.
7. Jian Feng Li, Jie Zhang, Ren Song, Jia Xin Zhang, Yang Shen and Shuang Quan Zhang*,Production of a cytotoxic cationic antibacterial peptide in Escherichia coli using SUMO fusion partner,Appl Microbiol Biot,84(2),383-388,2009
8. Jian Feng Li, Jie Zhang, Zhen Zhang, Hong Wei Ma, Jia Xin Zhang and Shuang Quan Zhang*,Production of Bioactive Human Beta-Defensin-4 in Escherichia coli Using SUMO Fusion Partner,Protein J,29(5),314-319,2010
9. Jian Feng Li, Jie Zhang, Zhen Zhang, Chun Tao Kang and Shuang Quan Zhang*,SUMO Mediating Fusion Expression of Antimicrobial Peptide CM4 from two Joined Genes in Escherichia coli,Curr Microbiol,62(1),296-300,2010
10. Jian Feng Li, Hong Xing Ai, Jie Zhang, Ming Xiang Du, Zhen Zhang, Jia Xin Zhang and Shuang Quan Zhang*,Molecular cloning, functional characterization and phylogenetic analysis of Trail in Japanese pufferfish Takifugu rubripes,J Fish Biol,79,747-760,2011
11. Jian Feng Li, Jie Zhang, Xing Zhou Xu, Yang Yang Han, Xian Wei Cui, Yu Qing Chen, Shuang Quan Zhang*,The antibacterial peptide ABP-CM4: the current state of its production and applications. Amino Acids,42,2393-2402,2012
12. Jian Feng Li, XianWei Cui, HaiYan Ji, Ting Qiu, Xue Mei Ji, Ming Xian Du, Hai Tao Wu, Xing Zhou Xu, Shuang Quan Zhang*,High efficient expression of bioactive human BMP-14 in E.coli using SUMO fusion partner,Protein J,30,592–597,2011