教育和工作经历

2013/09 – 2018/12，浙江大学，博士，导师：李永泉

2010/09 - 2013/07，山西大学，硕士，导师：裴雁曦

2006/09 - 2010/07，山西大学，生物科学，学士

联系方式

杭州师范大学基础医学院

Email: sjj2019@hznu.edu.cn

Tel: 0571-2886-5671

研究领域

基于生物大分子结构的微生物代谢产物合成机制研究。近五年围绕光合细菌和链霉菌体内代谢途径产生化工产品和免疫抑制药物的研究，明确了代谢途径中关键酶与产物产率的关系，为定向改造关键酶，获得高产菌株奠定基础，主持国家自然科学青年基金1项，参与重点国际合作项目、重点项目和面上基金等4项；发表SCI论文8篇。

主持科研项目

(1)   国家自然科学基金委员会, 青年科学基金项目, 32000034, 异质型乙酰辅酶A羧化酶在固碳中的催化机制, 2021-01至2023-12, 24万元, 在研, 主持。

(2)   杭州师范大学科研启动经费项目, 4125C5021920463, 他克莫司聚酮合酶中酰基转移酶底物选择性机制研究, 2019-01至2022-12, 10万, 在研, 主持。

代表性论著(* corresponding author)

[1]. Zhang C^#, Min Z^#, Liu X^#, Wang C^#, Wang Z, Shen J, Tang W, Zhang X, Liu D, Xu X*. Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima. FEBS Lett. 2020 Feb; 594(3):564-580.

[2]. Tang W^#, Wang Z^#, Zhang C^#, Wang C^#, Min Z, Zhang X, Liu D, Shen J, Xu X*. The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii. Biochem Biophys Res Commun. 2019 Oct 8; 518(1):72-79.

[3]. Shen J^#, Chen F, Wang X, Liu X, Chen X, Mao X*, Li Y*. Substrate specificity of acyltransferase domains for efficient transfer of acyl groups. Front Microbiol. 2018 Aug 7; 9:1840.

[4]. Shen J^#, Mao X, Chen X, Li Y*. Recent advances in acyltransferase domain of type I polyktide synthases. Chinese J Org Chem.. 2018 Jul 16, 38: 2377-2385.

[5]. Jiang H^#, Wang Y^#, Guo Y, Shen J, Zhang X, Luo H, Ren N, Jiang X, Li Y*. An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units. FEBS J. 2015 Jul, 282(13): 2527-2539.

[6]. Shen J^#, Xing T^#., Yuan H, Liu Z, Jin Z, Zhang L, Pei Y*. Hydrogen sulfide improves drought tolerance in Arabidopsis thaliana by microRNA expressions. Plos One. 2013 Oct 23, 8(10): e77047.

[7]. Shen J^#, Qiao Z^#, Xing T, Zhang L, Liang Y, Yang G, Wang R, Pei Y*. Cadmium toxicity is alleviated by AtLCD and AtDCD in Escherichia coli. J Appl Microbiol. 2012 Nov, 113(5): 1130-1138.

[8]. Jin Z^#, Shen J^#, Qiao Z, Yang G, Wang R, Pei Y*. Hydrogen sulfide improves drought resistance in Arabidopsis thaliana. Biochem Biophys Res Commun. 2011 Oct 28, 414(3): 481-486.