教育和工作经历

2021年-至今 杭州师范大学基础医学院，副教授;

2019年-2021年 德国维尔茨堡大学医院和Rudolf-Virchow-Zentrum研究所，博士后;

2018年-2019年 西班牙巴塞罗那自治大学，博士后;

2013年-2018年 西班牙巴塞罗那自治大学，生物化学、分子生物学与生物医学，博士;

2010年-2013年 华东理工大学，生物工程，硕士;

2006年-2010年 华东理工大学，生物技术，学士。

联系方式

杭州师范大学基础医学院

E-mail：bingliu@hznu.edu.cn

电话: 0571-2886-5671

研究领域

蛋白质、核酸等生物大分子基于其三维空间结构发挥功能。我们通过X-射线晶体学、冷冻电镜以及其它生物物理、生物化学等方法,系统研究重要生物大分子的结构和功能,比如在泛素化和SUMO化途径中与疾病相关的酶。我们致力于从分子层面理解生物大分子发挥功能的机制,加速药物的研发。

代表性论著(* corresponding author)

[1]  Nair, R. M., Seenivasan, A., Liu, B., Chen, D., Lowe, E. D., & Lorenz, S. (2021). Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe. ACS chemical biology, 16(9), 1615-1621.

[2]   Zhang, J.^#, Liu, B.^#, Gu, D.^#, Hao, Y., Chen, M., Ma, Y., ... & Wang, Q. (2021). Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression. Nucleic acids research, 49(6), 3274-3293. ^#Co-first author.

[3] Li, Y., Liu, B., & Reverter, D.* (2020), A Novel Regulatory Mechanism to Regulate the Deubiquitinating Activity of USP25 by Oligomerization. J Cell Signal 2020; 1(4): 151-154.

[4]  Liu, B., Lois, L. M., & Reverter, D.* (2019). Structural insights into SUMO E1-E2 interactions in Arabidopsis uncovers a distinctive platform for securing SUMO conjugation specificity across evolution. Biochemical Journal, BCJ20190232.

[5]  Liu, B., Sureda-Gómez, M., Zhen, Y., Amador, V. and Reverter, D.* (2018). A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25. Nature Communications 9, 4973.

[6]  Liu, B., Lois, L. M., & Reverter, D.* (2017). Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions. Scientific reports, 7, 41998.

[7]  Wei, L., Qiao, H., Liu, B., Yin, K., Liu, Q., Zhang, Y., ... & Wang, Q.* (2019). MarTrack: A versatile toolbox of mariner transposon derivatives used for functional genetic analysis of bacterial genomes. Microbiological research, 228, 126306.

[8] Yin, K., Guan, Y., Ma, R., Wei, L., Liu, B., Liu, X., ... & Wang, Q.* (2018). Critical role for a promoter discriminator in RpoS control of virulence in Edwardsiella piscicida. PLoS pathogens, 14(8), e1007272.

[9]  Xiao, J., Chen, T., Liu, B., Yang, W., Wang, Q.*, Qu, J., & Zhang, Y. (2013). Edwardsiella tarda mutant disrupted in type III secretion system and chorismic acid synthesis and cured of a plasmid as a live attenuated vaccine in turbot. Fish & shellfish immunology, 35(3), 632-641.

[10] Wang, Y., Wang, Q.*, Yang, W., Liu, B., & Zhang, Y. (2013). Functional characterization of Edwardsiella tarda twin-arginine translocation system and its potential use as biological containment in live attenuated vaccine of marine fish. Applied microbiology and biotechnology, 97(8), 3545-3557.

[11] Liang, S., Wu, H.*, Liu, B., Xiao, J., Wang, Q., & Zhang, Y. (2012). Immune response of turbot (Scophthalmus maximus L.) to a broad spectrum vaccine candidate, recombinant glyceraldehyde-3-phosphate dehydrogenase of Edwardsiella tarda. Veterinary immunology and immunopathology, 150(3-4), 198-205.