Lecture

School of Basic Medical Sciences, Hangzhou Normal University

Email: xinjiyu@hznu.edu.cn

Tel: 0571-2886-5671

Education

2020-       Lecturer, School of Medicine, Hangzhou Normal University

2014-2019   Ph.D. in Biochemistry and Molecular Biology, University of Science and Technology of China

2006-2010    B.S. in Biology, School of Life Science, Hainan University

Research Interest

My research interest is to study the structure of protein complex and develop effective clinical drugs based on the structure of biological molecules. We aim to clarify the molecular mechanisms of complex macromolecular systems through cryo-electron microscopy (cryo-EM), biochemical and cell biology methods, and promote its application in therapeutics and controllable drug development.

Selected publications

1.  Xin, J., Z. Xu, X. Wang, Y. Tian, Z. Zhang and G. Cai (2019). "Structural basis of allosteric regulation of Tel1/ATM kinase." Cell Res 29(8): 655-665.

2.  Zhang, Z., X. Wang, J. Xin, Z. Ding, S. Liu, Q. Fang, N. Yang, R. M. Xu and G. Cai (2018). "Architecture of SWI/SNF chromatin remodeling complex." Protein Cell 9(12): 1045-1049.

3.  Wang, X. J., T. T. Ran, X. Zhang, J. Y. Xin, Z. H. Zhang, T. W. Wu, W. W. Wang and G. Cai (2017). "3.9 angstrom structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP." Science 358(6367): 1206-1209.

Research Funds

General Research Project of Zhejiang Provincial Department of Education (Y202044875)