郦莉，1：深入研究端粒酶缺失小鼠的卵巢衰老表型，并鉴定在其中起关键作用的分子，确定端粒酶缺失导致小鼠卵巢衰老的分子机制；2：从事肝癌发生发展机制的研究，研究重点为运用肝细胞高效的基因编辑小鼠，系统性阐明多样化的基因突变导致肝癌表型异质性的规律和机制这一关键科学问题，为肝癌精准治疗新方案的开发提供科学依据和测试平台。主持国家自然科学基金2项，相关研究成果已发表于EMBO J，JBC，Genes&development等，发表SCI论文20余篇。
课程教学：讲授《生理学》、《基础医学概论》等本科生课程，参与讲授《高级生理学》研究生专业基础和选修课程。
教育背景
1. 2005/09-2011/02，美国密歇根大学，生物化学系，博士
2. 2003/09-2005/07，中科院上海植物生理生态研究所
3. 1999/09-2003/06，浙江大学，生命科学学院生物技术系，学士
主要工作简历
1. 2013/08-至今，杭州师范大学
2. 2011/06-2013/01，美国Sanford-Burnham Medical Research Institute，博士后，合作导师：Randal J. Kaufman
3. 2011/02-2011/05，美国加州大学圣地亚哥分校，药学系，博士后，合作导师：管坤良
主持科研项目
1. 国家自然科学基金面上项目，PTEN－端粒互作调控卵巢衰老的机制研究，2016/01-2019/12
2. 国家自然科学基金青年项目，PTEN－端粒互作调控细胞衰老的机制研究，2015/01-2017/12
代表性论著(* corresponding author)
1.Gong, R., Li, L., Liu, Y., Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K-L., Xu, Y. (2011). "Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation." Genes & Development 25(16): 1668-1673. 共一
2.Li, L. and K. L. Guan (2009). "Amino Acid Signaling to TOR Activation: Vam6 Functioning as a Gtr1 GEF." Molecular Cell 35(5): 543-545.
3.Li, L. and K. L. Guan (2013). "Microtubule-associated Protein/Microtubule Affinity-regulating Kinase 4 (MARK4) Is a Negative Regulator of the Mammalian Target of Rapamycin Complex 1 (mTORC1)." Journal of Biological Chemistry 288(1): 703-708.
4.Li, L., Kim, E., Yuan, H., Inoki, K., Goraksha-Hicks, P., Schiesher, R.L., Neufeld, T.P., Guan, K-L. (2010). "Regulation of mTORC1 by the Rab and Arf GTPases." Journal of Biological Chemistry 285(26): 19705-19709.
5.Zhao, B., Li, L., Lu, Q., Wang, L.H., Liu, C-Y., Lei, Q., Guan, K-L. (2011). "Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein." Genes & Development 25(1): 51-63. 共一
6.Zhu, C., Li, L. and Zhao, B. (2015). "The regulation and function of YAP transcription co-activator." Acta Biochimica Et Biophysica Sinica 47(1): 16-28. 共同通讯
7.Li, S., Han, S., Zhang, Q., Zhu, Y., Zhang, H., Wang, J., Zhao, Y., Zhao J., Su, L., Li, L., Zhou, D., Ye, C., Feng, X-H., Liang, T., Zhao, B. (2022). "FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion." Nature Communications 13(1).
8.Tang, M., Zhao, Y., Zhao, J., Wei, S., Liu, M., Zheng, N., Geng, D., Han, S., Zhang, Y., Zhong, G., Li, S., Zhang, X., Wang, C., Yan, H., Cao, X., Li, L., Bai, X., Ji, J., Feng, X-H., Qin, J., Liang, T., Zhao, B. (2022). "Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes." Science Advances 8(25).
9.Zhou, Q., Hao, B., Cao, X., Gao, L., Yu, Z., Zhao, Y., Zhu, M., Zhong, G., Chi, F., Dai, X., Mao, J., Zhu, Y., Rong, P., Chen, L., Bai, X., Ye, C., Chen, S., Liang, T., Li, L., Feng, X-H., Tan, M., Zhao, B. (2022). "Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha." Molecular Cell 82(24): 4700-+.
